Pages tagged with DNA damage

Checkpoints

Checkpoints are crucial events in a cells life that are highly regulated. The checkpoints prevent the cell from losing control of its genetic...

DNA damage

There are many processes that can damage DNA: 1. Exogenous proceses, like radiation and chemicals 2. Endogenous processed, like a mutation...

DNA polymerase eta (DNA polη)

DNA polymerase eta (pol eta) is one of few DNA polymerases that can bypass damage in the DNA during replication. This decreases the risk of greater...

S-phase (Synthesis-phase)

In S-phase the genome is duplicated in a process called DNA replication. The DNA replication is preformed by a large protein complex collectively...

Xeroderma pigmentosum variant (XPV)

1979 J.E. Cleaver et al determined that “pigmented xerodermoid” cells could repair the UV- damage tested to determine XP cells at the same level as...

Replication

Replication is the process of duplicating DNA in preparation for cell division. The replication mechanism in short consist of prying the DNA helix...

DNA polymerases

DNA polymerases are responsible for bypassing damage in the DNA during replication. If the damage is not bypassed the group of proteins driving the...

POLH gene

The POLH gene is 40kbp long and contains 11 exons, that generate a 2432bp long mRNA.[1] Unlike in mice, there is no higher incidence of skin cancer...

Low-fidelity DNA polymerases

Low-fidelity DNA polymerases allow for translesion synthesis, the process of overlooking DNA damage during replication and matching the damaged...

Cyclobutane pyrimidine dimers (CPDs)

CPDs can form when two pyrimidine nucleotides (C or T) next to each other in the DNA are exposed to UV-light. CPD is the most abundant form of...

Translesion Synthesis (TLS)

Lesions, or DNA damage, can lead to complications during the replication process. Some proteins, like DNA polymerases that can bypass damage in the...